Pipeline

Transforming Growth Factor-alpha

TGFα is an endogenous 50 amino acid growth factor with no posttranslational modifications. TGFα has been shown to protect against acute neuronal cell death in animal models of stroke. NeuroRepair is currently developing TGFα applications for the treatment of acute and chronic stroke and plans to begin preclinical testing in primates.


Future Indications

TGFα also induces massive proliferation, migration and differentiation of new neurons in the damaged adult brain. The degree of proliferation and migration is orders of magnitude over any other growth factor or synthetic small molecule.

In the long term, NeuroRepair plans to develop applications respecting the use of TGFa for treatment of central nervous system disorders and injuries, including stroke, Alzheimer’s disease, Parkinson disease, spinal cord injury, retinal disorders, and brain injury from head trauma.

Intranasal_MCAO_Stroke

TGF causes Proliferation, Migration and Differentiation of Neural Stem cells

Rats receiving an infusion of TGFa after brain injury to the striatum (cartooned in purple) demonstrate massive proliferation of stem cells in the subventricular zone (SVZ) which migrate in a ridge toward the site of the injury. New cells express markers of differentiating glial cells and neurons. Adapted from Fallon et al., 2000, 2006.
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